Kamagra Oral Jelly

Kamagra Oral Jelly is used for erectile dysfunction treatment. This drug restores reduced erectile function, increasing blood flow to the penile smooth muscles. The mechanism of action is based on the release of nitric oxide in the cavernous bodies at the time of sexual excitement. Free nitric oxide activates the guanylate cyclase enzyme, stimulating an increase in the level of cGMP. Consequently, it causes relaxation of the smooth muscle fibers of the corpora cavernosa and an increase in blood flow.

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Dosage and administration

One sachet is intended for single use only – open it and use all the contents. Apply strictly under medical supervision.

Kamagra should be taken approximately one hour before sexual intercourse. The recommended dose of Kamagra Oral Jelly is 50 mg and is taken before meals. Considering the effectiveness and tolerability, the drug dose can be increased to 100 mg or reduced to 25 mg.

The maximum recommended dose of jelly drug is 100 mg. The maximum recommended frequency of taking the drug is 1 time per day.

Side effects

• Very often: headache
• Often: dizziness, color distortions of vision (chloropsy, chromatopsia, cyanopsia, erythropsy, xantopsia), visual disturbance, blurred vision, hyperemia, hot flashes, nasal congestion, dyspepsia, nausea.
• Infrequently: rhinitis, hypersensitivity, drowsiness, hypesthesia, disorders associated with lacrimation (dry eyes, dysfunction of the lacrimal gland, increased lacrimation), eye pain, photophobia, photopsia, hyperemia of the vessels of the eyes, the brightness of visual perception, conjunctivitis, vertigo, tinnitus, tachycardia, palpitations, arterial hypertension, arterial hypotension, nosebleeds, nasal sinuses, pain in the upper abdomen, gastroesophageal reflux disease, vomiting, dry mouth, rash, myalgia, pain in the limbs, hematuria, chest pain, fatigue, feeling of heat, increased heart rate.
• Rarely: acute cerebrovascular accident, transient ischemic attack, seizure, relapse of a seizure, fainting, anterior non-arteritic ischemic optic neuropathy, retinal vascular occlusion, retinal hemorrhage, arteriosclerotic retinopathy, retinal disease, glaucoma, visual field defect, diplopia, decreased visual acuity, myopia, asthenopia, floating vitreous clouding, disease , the presence of rainbow circles in the field of vision, swelling of the eye, swelling of the eye, visual disturbances, conjunctival hyperemia, eye irritation, unusual sensation in the eye, swelling of the eyelids, discoloration of the sclera, deafness, sudden cardiac death, myocardial infarction, ventricular arrhythmia, atrial fibrillation, unstable angina pectoris, a feeling of tightness in the throat, swelling of the nose, dryness of the nasal mucosa, oral hypesthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, bleeding from the penis, priapism, hematospermia, increased erection, irritability side effects recorded only during post-registration monitoring.

Contraindications

• Hypersensitivity to any component of the drug;
• Simultaneous administration of drugs that are donors of nitric oxide (amyl nitrite) or nitrates in any form;
• Concomitant use with guanylate cyclase stimulants (riotsiguat);
• Severe liver failure;
• Hereditary degenerative diseases of the retina (for example, hereditary retinitis pigmentosa);
• Loss of vision in one eye due to anterior non-arteritic ischemic neuropathy of the optic nerve, regardless of whether this episode was associated with previous use of a PDE-5 inhibitor or notarterial hypotension;
• Severe cardiovascular disease (e.g., severe heart failure, unstable angina pectoris);
• Myocardial infarction suffered in the last 6 months;
• Stroke suffered in the last 6 months;
• Men with rare hereditary galactose intolerance, Lapp lactase deficiency or glucose and galactose malabsorption syndrome;
• Simultaneous administration with other oral or local agents for the treatment of erectile dysfunction.

Drug interactions

The effect of other drugs on Kamagra Oral Jelly (Sildenfil)

Sildenafil metabolism is predominantly caused by cytochrome P450 (CYP), isoforms 3A4 (main metabolic pathway) and 2C9 (secondary metabolic pathway). Therefore, inhibitors of these isoenzymes can affect sildenafil clearance.

Cimetidine (800 mg), a non-specific inhibitor of CYP, causes a 56% increase in plasma concentration of the drug while taking sildenafil (50 mg) in healthy volunteers.

Potent CYP3A4 inhibitors such as ketoconazole, itraconazole or mibefradil are considered to have a stronger effect. Clinical studies have shown a decrease in clearance of sildenafil in patients while taking it with CYP3A4 inhibitors. It should be expected that concomitant use of CYP3A4 inducers, such as rifampicin, may decrease the level of plasma sildenafil concentration.

A single dose of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of sildenafil.

Kamagra Oral Jelly effect on other drugs

In vitro studies: the drug is a weak inhibitor of cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50> 150 mM). At maximum plasma concentrations of the drug, approximately 1 mM after administration at the recommended doses, it is unlikely that the drug will affect the clearance of the substrates of these isoenzymes.

In vivo studies: no significant interactions were recorded when taken concomitantly with tolbutamide (250 mg) or warfarin (40 mg), which are both metabolized by CYP2C9.

Kamagra Oral Jelly (50 mg) does not affect the increase in bleeding time caused by aspirin (150 mg).

Kamagra Oral Jelly (50 mg) does not enhance the hypotensive effect of alcohol in healthy volunteers with an average maximum blood alcohol level of 0.08%.

When Kamagra Oral Jelly 100 mg is taken simultaneously with amlodipine in hypertensive patients, an additional decrease in blood pressure in the supine position has a similar magnitude observed when taking only one drug in healthy volunteers.